Scientists building tech for science.
Praxis Science (PraxSci) is building a bridge between traditional science (TradSci) and tech-enabled decentralized science (DeSci).
PraxSci is designed to help the science community help humanity. We have put scientists as our top stakeholder from Day 1 and continually gather feedback from our growing community as a perpetual peer-review.
Our community brings together researchers who've been displaced, disrupted or disheartened with the current state of science and its support.1 It gives them a virtual home where they can keep their important work going despite the curveballs life may throw their way. We've built this digital space where brilliant minds can connect, share ideas, and support each other through transitions—whether they're dealing with relocations, institutional changes, or other disruptions that might otherwise slow their research momentum.
Find more information about Terminus at terminus.praxisscience.com
PraxSci builds on what has made science successful for hundreds of years. We use the core governance from TradSci while adapting it to correct problems and enable technology to bring it into the future.
We are helping to facilitate the trend of increased multi-organizational publications, including unaffiliated scientists. This can disintermediate to a degree both institutions and labs/PIs to find a new homeostasis for optimizing scientific output in an environment with increased unaffiliated and small org affiliated authors working together. We don't seek to increase the rate of publications, but to improve the quality, comprehensiveness and complexity by facilitating the development of rigorous, novel and impactful multi-party and multi-perspective manuscripts across scientific fields.2
PraxSci tech is being designed with input from science and scientists. We focus on scientists' input and scientific evidence base that is critical for separating signal from noise in science.
At the heart of this push ahead with artificial intelligence (AI) is the notion of Sci-Slop – the concept of flawed science and research rooted in the training of an AI model on unvalidated data.4 While there is validity to the use of AI in research efforts and there has been an acceleration of biomarker identification and drug discovery5, it is crucial to recognize that the acceleration of science can lead to a loss of validation, the creation of too many papers and issues with reproducibility as the black box of AI doesn't always allow for transparency in the science.4
This issue is not only the data coming out, but the data going in. Unvalidated and unverified data that comes from sources scraped from the internet can lead to confusing hallucinations generated by large language models. The need for validated, verified datasets is becoming more critical as more users depend on the results of these models for their healthcare and research decisions.
Our prototype is a blockchain-based solution that provides an immutable system for credentialing, validation, and verification. This solution relies on decentralization and cryptography as well as human in the loop reviews aided by a credentialing system that identifies authors and tracks the provenance of data over time to ensure quality. The prototype system was the first place winner of the 2026 Hackathon 4 Humanity hosted by the Duquesne University Grefenstette Center.
Scientia machina is a proposed conceptual framework for a technology-accelerated system of biomedical science. It identifies key layers of trust in the framework of biomedical science and explores how technologies and can be evaluated and introduced into the process in an efficient and functional manner. The entire framework can be found here in the Frontiers in Systems Biology..3
Integrative Roadmap
Phase 1 (Apr – May 2025): Terminus Launch COMPLETE
Phase 2 (Jun - Aug 2025): dPub Initiated COMPLETE
Phase 3 (Sep – Nov 2025): CoAuth - a community tool for dPub facilitation
Phase 4 (Mar 2026 – Apr 2028): The Invisible College, Decentralized (launched as Conscientiâ)
Phase 5 (Apr – Aug 2026): Science Associates - Science Targeted Expert Model (STEM) Agents
Who We Are
Sean Manion is a neuroscientist with two decades of federal research and science policy experience. In 2017 he moved to the tech sector to explore blockchain and artificial intelligence applications in science and medicine. He co-founded the section Blockchain for Science at the journal Frontiers in Blockchain in 2018 and co-authored the book Blockchain for Medical Research (CRC Press, 2020). He currently serves as adjunct faculty in the Psychology Department at Duquesne University and as co-editor of the section Systems Concepts, Theory and Policy in Biology and Medicine at the journal Frontiers in Systems Biology.
Kris Rockwell operates at the intersection of venture capital, emerging technology, and philanthropic leadership. With more than fifteen years of experience in the eLearning industry, he subsequently led the S. Kent Rockwell Foundation, advancing initiatives in conservation, entrepreneurship, and addiction recovery. He currently serves as President of the Kris Rockwell Foundation, Founder of AoS Ventures — a Pittsburgh-based venture capital firm — Head of Product Development at Play Piper, Inc., a San Francisco-based edtech company, and Co-Founder of Praxis Science, which applies artificial intelligence and blockchain technologies to decentralized scientific research. Kris also serves on the boards of the Bonefish & Tarpon Trust, The Kiski School, and Indifly. He is currently pursuing a PhD in Information Systems and Communications at Robert Morris University.
- Praxis Science, "Terminus," Praxis Science, accessed June 19, 2025, https://terminus.praxisscience.com
- Hottenrott H, Rose ME, Lawson C. The rise of multiple institutional affiliations in academia. J Assoc Inf Sci Technol. 2021; 72: 1039–1058. https://doi.org/10.1002/asi.24472
- Manion ST (2025) Scientia machina: a proposed conceptual framework for a technology-accelerated system of biomedical science. Front. Syst. Biol. 5:1576989. doi: 10.3389/fsysb.2025.1576989
- Manion, S (2025, October 2). Decentralized Science: What and why? [Conference presentation]. DeSAI: The Impact of New Tech on Science: The Good, the Bad & the Future, Pittsburgh, PA.
- Lyu, Y.-X., Fu, Q., Wilczok, D., Ying, K., King, A., Antebi, A., Vojta, A., Stolzing, A., Moskalev, A., Georgievskaya, A., Maier, A. B., Olsen, A., Groth, A., Simon, A. K., Brunet, A., Jamil, A., Kulaga, A., Bhatti, A., Yaden, B., … Bakula, D. (2024). Longevity biotechnology: Bridging AI, biomarkers, geroscience and clinical applications for healthy longevity. Aging. https://doi.org/10.18632/aging.206135